DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by using a few nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucleic acid substrates have https://clivem901vng4.kylieblog.com/profile