This system is most likely through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical reaction to doxycycline should be monitored closely. Phenytoin, sodium valproate, valproic acid: The influence of barbiturates on the metabolism of phenytoin seems to become variable. https://tonyh935rtt0.wikiworldstock.com/user