At 3 times post-MPTP, we discovered substantial microglial activation and up-regulation of CB2 cannabinoid receptors while in the ventral midbrain. Therapy with Gain or even the CB2 receptor agonist JWH015 (4 mg/kg, intraperitoneal) lowered MPTP-induced microglial activation, whereas genetic ablation of CB2 receptors exacerbated MPTP systemic toxicity. In addition, Continual https://win55.clinic/tin-tuc