Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment inte... https://dicen665crg2.blogrenanda.com/profile